In this paper, we study the formation of conflicts in the strategic change of enterprises from the micro level under the perspective of cognition. First of all, we illuminate the connotation and category of conflict and analyze the general causes of the formation of conflict and the causes of strategic change from the perspective of cognitive subject, cognition and cognitive object. Then, we take the process of strategic change as the main line to analyze the differences of role orientation, attention and cognitive schema between top, middle and executive managers. By doing do, we find out the mechanism of the cognitive conflict of task, the cognitive conflict of process and the cognitive conflict of relationship from the vertical and horizontal perspectives. As a result, the theoretical model formed by conflict in the process of the strategic change of enterprise is constructed. Finally, we take China Aerospace Science and Technology Group Co., Ltd. as the research sample and make an empirical study by means of questionnaires. The result shows that the perception of strategic change is positively correlated with the conflict of it, in which the strategic change is positively correlated with the cognitive conflict of task and the cognitive conflict of relationship, while strategic change is not correlated with the cognitive conflict of process.