Integrating the institution-based view and resource-based view in a unified framework, this paperexamines the internal influence mechanism of institutional distance between different regions on trans-regional market entry modes choice by questionnaire survey of 150 firm-level samples, and obtains the following three conclusions. First, the institutional distance between the host and the home regions has negative influences on the level of resource commitment, control, and equity ownership for market entry mode. Second, trans-regional business experience has positive influences on the level of resource commitment, control, and equity ownership for market entry mode. Finally, there exists interaction effect on the level of resource commitment, control, and equity ownership for market entry mode between institutional distance and trans-regional business experience. These results have critical implications for business decisions of trans-regional firms.