Abstract: To depict the interaction effect between emergency resource allocation and epidemic spread,an innovative decision-making framework model is constructed in this paper.The new decision-making framework not only considers the influence of population mitigation among different infected areas,but also integrates the key factors such as the limited number of isolation wards under the condition of limited emergency budget and together with a time-varying patient admission rate.Based on the idea of knapsack problem,a mixed integer non-linear programming model for allocating the limited emergency budget is proposed.The model is then linearized and thus it can be solved directly.The test results demonstrate that emergency budget should be inclined to population inflow areas.More than that,there are threshold effects in both emergency budget and initial intervention time.After the threshold is exceeded,even a higher emergency budget does not work for epidemic controlling.

Key words: epidemic outbreak, epidemic model, emergency resource allocation, interaction, system optimization